Further Observations on Use of D-penicillamine in Cystinuria

Further Observations on Use of D-penicillamine in Cystinuria.

It was shown in a previous communication (Crawhall et al., 1963) that the abnormally high level of cystine excretion found in homozygotes for cystinuria could be reduced for short periods by the administration of D-penicillamine. This paper reports the results of administering the drug continuously to a group of cystinuric patients for periods of five months to one year. We have used the D-isom...

The use of D-penicillamine in cystinuria: efficacy and untoward reactions.

A retrospective study was conducted to assess the efficacy of D-penicillamine in the management of cystinuria, as well as to define the frequency and nature of untoward reactions to this drug. Fifty-six individuals were identified who, by stone analysis and/or biochemical studies, met the accepted diagnostic criteria for phenotypic cystinuria. The majority of these patients presented in the sec...

New Agent in the Treatment of Cystinuria: N-acetyl-D-penicillamine.

Further Observations on the Use of Adrenalin in Plague

In a previous communication to this journal * the preliminary observations with adrenalin were related. They indicated that adrenalin exerted a distinctly beneficial effect upon the circulation by increasing the pulse tension, remedying its irregularities and steadying and sustaining the action of the heart, until such time as the system was able to eliminate the toxins, and bring about recover...

Use of D-Penicillamine in the Neonatal Hyperbilirubinemias

It appears that bilirubin IXᾰ has unique structural properties which might have been predicted on the basis of modern concepts of organic chemistry but whose biological implications certainly were not fully appreciated [1]. The initial breakdown product of haemoglobin is UCB (unconjegated or indirect bilirubin) which is insoluble in water but soluble in lipids. This process is catalyzed by an i...